Other forms: radicals
If something is considered extremist or very different from anything that has come before it, call it radical.
The noun, radical, comes from the Latin radix "root," and in fact, radical and root are synonymous as technical terms in fields such as math and linguistics. In more everyday language, a radical is someone who has very extreme views, so you could say that their views are different from the root up. Similarly, a radical flaw or change is a fundamental one whereas a radical design or idea is very new and innovative.